• Équipe EPAR

    L'équipe "Épidémiologie des maladies Allergiques et Respiratoires" est intégrée à l'Unité INSERM UMR-S 1136, Institut Pierre Louis d'Epidémiologie et Santé Publique, regroupe 6 Group Leaders, 12 chercheurs ou enseignants chercheurs,2 personnels techno-administratifs, 3 doctorants et 1 post-doc.

  • Les maladies allergiques et respiratoires

    touchent une partie importante de la population et on leur associe des coûts sociaux et économiques importants. Depuis quelques décennies, la prévalence de ces affections n'a cessé d'augmenter. Les causes et les mécanismes de cet accroissement n'ont pas encore été élucidés. Les travaux menés par l'équipe d'EPidémiologie des maladies Allergiques et Respiratoires (EPAR) ont pour but d'approfondir la recherche étiologique des principales maladies allergiques et respiratoires (rhinite, asthme, BPCO, cancer du poumon...), d'identifier les sujets à risque, et de déterminer les coûts associés. L'hypothèse à la base de ces recherches est que l'augmentation des maladies allergiques et respiratoires est due à la fois à des changements de type environnemental et à des modifications de la « sensibilité » de l'hôte. Dans ce contexte, les facteurs de risque, de susceptibilité et de vulnérabilité sont identifiés.

  • Les axes de recherche

    Les principaux axes de recherche qui vont être développés dans les années à venir sont :

    • Impact de la pollution atmosphérique sur les maladies allergiques et respiratoires.
    • Événements de la vie précoce et développement des maladies allergiques et respiratoires.
    • Dossiers patients via le web (e-BPCO, e-Muco, e-dev...).

    Isabella Annesi-Maesano
    Directeur de Recherche INSERM
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Bienvenue sur le site de l'équipe EPAR

1. Amat F, Boutmy-Deslandes E, Desseaux K, Nemni A, Bourrat E, Sarahoui F, Panse E, Fouere S, Bagot M, Just J. Multiple sensitisation to food allergens predisposes to develop sensitisation to inhaled allergens in infants with early-onset atopic dermatitis: evidence from the ORCA prospective cohort. Allergy 2014; 69: 93-93.

2. Annesi-Maesano I, Lundback B, Viegi G. Respiratory Epidemiology Introduction. In: AnnesiMaesano I, Lundback B, Viegi G, Welte T, editors. Respiratory Epidemiology; 2014. p. XIV-XVII.

3. Annesi-Maesano I, Roche N. Healthy behaviours and COPD. European respiratory review : an official journal of the European Respiratory Society 2014; 23: 410-415.

4. Araujo-Martins J, Martins PC, Viegas J, Aelenei D, Cano MM, Teixeira JP, Paixao P, Papoila AL, Leiria-Pinto P, Pedro C, Rosado-Pinto J, Annesi-Maesano I, Neuparth N. Environment and Health in Children Day Care Centres (ENVIRH) - Study rationale and protocol. Revista Portuguesa De Pneumologia 2014; 20: 311-323.

5. Baiz N, Dargent-Molina P, Wark JD, Souberbielle J-C, Annesi-Maesano I, Eden Mother-Child Cohort Study G. Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis. Journal of Allergy and Clinical Immunology 2014; 133: 147-153.

6. Benaissa F, Alkama R, Annesi-Maesano I. Assessment of Air Pollution Impacts on Population Health in Bejaia City, Northern Algeria. Iranian Journal of Public Health 2014; 43: 1221-1228.

7. Bergmann K-C, Demoly P, Worm M, Fokkens WJ, Carrillo T, Tabar AI, Nguyen H, Montagut A, Zeldin RK. Efficacy and safety of sublingual tablets of house dust mite allergen extracts in adults with allergic rhinitis. Journal of Allergy and Clinical Immunology 2014; 133: 1608-+.

8. Botton J, Scherdel P, Regnault N, Heude B, Charles M-A, Grp EM-CCS. Postnatal Weight and Height Growth Modeling and Prediction of Body Mass Index as a Function of Time for the Study of Growth Determinants. Annals of Nutrition and Metabolism 2014; 65: 156-166.

9. Bousquet J, Addis A, Adcock I, Agache I, Agusti A, Alonso A, Annesi-Maesano I, Anto JM, Bachert C, Baena-Cagnani CE, Bai C, Baigenzhin A, Barbara C, Barnes PJ, Bateman ED, Beck L, Bedbrook A, Bel EH, Benezet O, Bennoor KS, Benson M, Bernabeu-Wittel M, Bewick M, Bindslev-Jensen C, Blain H, Blasi F, Bonini M, Bonini S, Boulet LP, Bourdin A, Bourret R, Bousquet PJ, Brightling CE, Briggs A, Brozek J, Buhl R, Bush A, Caimmi D, Calderon M, Calverley P, Camargos PA, Camuzat T, Canonica GW, Carlsen KH, Casale TB, Cazzola M, Cepeda Sarabia AM, Cesario A, Chen YZ, Chkhartishvili E, Chavannes NH, Chiron R, Chuchalin A, Chung KF, Cox L, Crooks G, Crooks MG, Cruz AA, Custovic A, Dahl R, Dahlen SE, De Blay F, Dedeu T, Deleanu D, Demoly P, Devillier P, Didier A, Dinh-Xuan AT, Djukanovic R, Dokic D, Douagui H, Dubakiene R, Eglin S, Elliot F, Emuzyte R, Fabbri L, Fink Wagner A, Fletcher M, Fokkens WJ, Fonseca J, Franco A, Frith P, Furber A, Gaga M, Garces J, Garcia-Aymerich J, Gamkrelidze A, Gonzales-Diaz S, Gouzi F, Guzman MA, Haahtela T, Harrison D, Hayot M, Heaney LG, Heinrich J, Hellings PW, Hooper J, Humbert M, Hyland M, Iaccarino G, Jakovenko D, Jardim JR, Jeandel C, Jenkins C, Johnston SL, Jonquet O, Joos G, Jung KS, Kalayci O, Karunanithi S, Keil T, Khaltaev N, Kolek V, Kowalski ML, Kull I, Kuna P, Kvedariene V, Le LT, Lodrup Carlsen KC, Louis R, MacNee W, Mair A, Majer I, Manning P, de Manuel Keenoy E, Masjedi MR, Melen E, Melo-Gomes E, Menzies-Gow A, Mercier G, Mercier J, Michel JP, Miculinic N, Mihaltan F, Milenkovic B, Molimard M, Momas I, Montilla-Santana A, Morais-Almeida M, Morgan M, N'Diaye M, Nafti S, Nekam K, Neou A, Nicod L, O'Hehir R, Ohta K, Paggiaro P, Palkonen S, Palmer S, Papadopoulos NG, Papi A, Passalacqua G, Pavord I, Pigearias B, Plavec D, Postma DS, Price D, Rabe KF, Radier Pontal F, Redon J, Rennard S, Roberts J, Robine JM, Roca J, Roche N, Rodenas F, Roggeri A, Rolland C, Rosado-Pinto J, Ryan D, Samolinski B, Sanchez-Borges M, Schunemann HJ, Sheikh A, Shields M, Siafakas N, Sibille Y, Similowski T, Small I, Sola-Morales O, Sooronbaev T, Stelmach R, Sterk PJ, Stiris T, Sud P, Tellier V, To T, Todo-Bom A, Triggiani M, Valenta R, Valero AL, Valiulis A, Valovirta E, Van Ganse E, Vandenplas O, Vasankari T, Vestbo J, Vezzani G, Viegi G, Visier L, Vogelmeier C, Vontetsianos T, Wagstaff R, Wahn U, Wallaert B, Whalley B, Wickman M, Williams DM, Wilson N, Yawn BP, Yiallouros PK, Yorgancioglu A, Yusuf OM, Zar HJ, Zhong N, Zidarn M, Zuberbier T, European Innovation Partnership on A, Healthy Ageing A, Plan B, Mechanisms of the Development of Allergy WP, Global Alliance against Chronic Respiratory D. Integrated care pathways for airway diseases (AIRWAYS-ICPs). The European respiratory journal 2014; 44: 304-323.

10. Bousquet J, Addis A, Adcock I, Agache I, Agusti A, Alonso A, Annesi-Maesano I, Anto JM, Bachert C, Baena-Cagnani CE, Bai C, Baigenzhin A, Barbara C, Barnes PJ, Bateman ED, Beck L, Bedbrook A, Bel EH, Benezet O, Bennoor KS, Benson M, Bernabeu-Wittel M, Bewick M, Bindslev-Jensen C, Blain H, Blasi F, Bonini M, Bonini S, Boulet LP, Bourdin A, Bourret R, Bousquet PJ, Brightling CE, Briggs A, Brozek J, Buhl R, Bush A, Caimmi D, Calderon M, Calverley P, Camargos PA, Camuzat T, Canonica GW, Carlsen KH, Casale TB, Cazzola M, Sarabia AMC, Cesario A, Chen YZ, Chkhartishvili E, Chavannes NH, Chiron R, Chuchalin A, Chung KF, Cox L, Crooks G, Crooks MG, Cruz AA, Custovic A, Dahl R, Dahlen SE, De Blay F, Dedeu T, Deleanu D, Demoly P, Devillier P, Didier A, Dinh-Xuan AT, Djukanovic R, Dokic D, Douagui H, Dubakiene R, Eglin S, Elliot F, Emuzyte R, Fabbri L, Wagner AF, Fletcher M, Fokkens WJ, Fonseca J, Franco A, Frith P, Furber A, Gaga M, Garces J, Garcia-Aymerich J, Gamkrelidze A, Gonzales-Diaz S, Gouzi F, Guzman MA, Haahtela T, Harrison D, Hayot M, Heaney LG, Heinrich J, Hellings PW, Hooper J, Humbert M, Hyland M, Iaccarino G, Jakovenko D, Jardim JR, Jeandel C, Jenkins C, Johnston SL, Jonquet O, Joos G, Jung KS, Kalayci O, Karunanithi S, Keil T, Khaltaev N, Kolek V, Kowalski ML, Kull I, Kuna P, Kvedariene V, Le LT, Carlsen KCL, Louis R, MacNee W, Mair A, Majer I, Manning P, Keenoy EdM, Masjedi MR, Meten E, Melo-Gomes E, Menzies-Gow A, Mercier G, Mercier J, Michel JP, Miculinic N, Mihaltan F, Milenkovic B, Molimard M, Mamas I, Montilla-Santana A, Morais-Almeida M, Morgan M, N'Diaye M, Nafti S, Nekam K, Neou A, Nicod L, O'Hehir R, Ohta K, Paggiaro P, Palkonen S, Palmer S, Papadopoulos NG, Papi A, Passalacqua G, Pavord I, Pigearias B, Plavec D, Postma DS, Price D, Rabe KF, Pontal FR, Redon J, Rennard S, Roberts J, Robine JM, Roca J, Roche N, Rodenas F, Roggeri A, Rolland C, Rosado-Pinto J, Ryan D, Samolinski B, Sanchez-Borges M, Schunemann HJ, Sheikh A, Shields M, Siafakas N, Sibille Y, Similowski T, Small I, Sola-Morales O, Sooronbaev T, Stelmach R, Sterk PJ, Stiris T, Sud P, Tellier V, To T, Todo-Bom A, Triggiani M, Valenta R, Valero AL, Valiulis A, Valovirta E, Van Ganse E, Vandenplas O, Vasankari T, Vestbo J, Vezzani G, Viegi G, Visier L, Vogelmeier C, Vontetsianos T, Wagstaff R, Wahn U, Wallaert B, Whalley B, Wickman M, Williams DM, Wilson N, Yawn BP, Yiallouros PK, Yorgancioglu A, Yusuf OM, Zar HJ, Zhong N, Zidarn M, Zuberbier T. Integrated care pathways for airway diseases (AIRWAYS-ICPs). European Respiratory Journal 2014; 44: 304-323.

11. Bousquet J, Bachert C, Price D, Acaster S, Demoly P. Assessing allergic rhinitis symptom control using a simple visual analogue scale: the digital solution. Allergy 2014; 69: 134-134.

12. Bousquet J, Bourdin A, Demoly P. Do we need new asthma control tests? European Respiratory Journal 2014; 44: 1116-1118.

13. Bousquet J, Bourdin A, Demoly P. Safety of beta(2)-agonists: a 50-year debate closed? European Respiratory Journal 2014; 43: 6-9.

14. Bousquet J, Bourquin C, Auge P, Domy P, Bringer J, Aoustin M, Camuzat T, Bourret R, Best N, Jonquet O, de la Coussaye JE, Robine JM, Avignon A, Blain H, Giraudeau N, Heve D, Jeandel C, Laffont I, Laney D, Laurent C, Nogues M, Pelissier JY, Radier-Pontal F, Royere E, Bedbrook A, Granier S, Abecassis F, Albert S, Adnet PA, Alomene B, Amouyal M, Arnavieilhe S, Attalin V, Aubas P, Badin M, Baptista G, Bardy B, Battesti MP, Benezet O, Bernard PL, Berr C, Berthe J, Bockaert J, Boubakri C, Bourdin A, Bourrain JL, Bourrel G, Bouix V, Burille J, Cade S, Caimmi D, Calmels MV, Camu W, Cavalli G, Cayla G, Chiron R, Combe B, Costa D, Costa P, Courrouy-Michel MC, Courtet P, Cristol JP, Cuisinier F, Daien C, Danko M, Dauenhauer P, Dauzat M, David M, Davy JM, Delignieres D, Demoly P, Dhivert-Donnadieu H, Dray G, Dujols P, Dupeyron A, Dupeyron G, Engberink O, Fesler P, Gellerat-Rogier M, Gouzi F, Gressard F, Hoa D, Jacquemin S, Gris JC, Guillot B, Handweiler V, Hayot M, Jaber S, Jakovenko D, Jorgensen C, Joumot L, Kaczorek M, Lapierre M, Laune D, Leglise MS, Le Quellec A, Leclerc F, Lehmann S, Lognos B, Lussert JM, Mandrick K, Marmelat V, Martin-Gousset P, Matheron A, Mathieu G, Mercier G, Messner P, Meunier C, Mondain M, Morel J, Morquin D, Nerin P, Ninot G, Nouvel F, Ortiz JP, Pandraud G, Pasdelou MP, Pasquie JL, Pastor E, Perrey S, Pers YM, Picot MC, Pin JP, Pinto N, Portejoie F, Pujol JL, Quantin X, Quere I, Raffort N, Ramdani S, Reynes J, Ribstein J, Redini-Martinez I, Richard S, Ritchie K, Rolland C, Roubille F, Roux E, Salvat A, Savy JL, Stephan Y, Strubel D, Sultan A, Tallon G, Tassery H, Torre K, Uziel A, Van de Perre P, Vasquez X, Verdier JM, Vergotte G, Vian L, Viarouge-Reunier C, Vialla F, Viart F, Villain M, Viollet E, Ankri J, Berrut G, Crooks G, Joel ME, Michel JP, Samolinski B, Strandberg T, Vellas B, Mercier J. MACVIA-LR, Reference site of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) in Languedoc Roussillon. European Geriatric Medicine 2014; 5: 406-415.

15. Bousquet J, Jorgensen C, Dauzat M, Cesario A, Camuzat T, Bourret R, Best N, Anto JM, Abecassis F, Aubas P, Avignon A, Badin M, Bedbrook A, Blain H, Bourdin A, Bringer J, Camu W, Cayla G, Costa DJ, Courtet P, Cristol J-P, Demoly P, de la Coussaye J-E, Fesler P, Gouzi F, Gris J-C, Guillot B, Hayot M, Jeandel C, Jonquet O, Journot L, Lehmann S, Mathieu G, Morel J, Ninot G, Pelissier J, Picot M-C, Radier-Pontal F, Robine J-M, Rodier M, Roubille F, Sultan A, Wojtusciszyn A, Auffray C, Balling R, Barbara C, Cambon-Thomsen A, Chavannes NH, Chuchalin A, Crooks G, Dedeu A, Fabbri LM, Garcia-Aymerich J, Hajjam J, Gomes EM, Palkonen S, Piette F, Pison C, Price D, Samolinski B, Schuenemann HJ, Sterk PJ, Yiallouros P, Roca J, Van de Perre P, Mercier J. Systems Medicine Approaches for the Definition of Complex Phenotypes in Chronic Diseases and Ageing. From Concept to Implementation and Policies. Current Pharmaceutical Design 2014; 20: 5928-5944.

16. Bousquet J, Klimek L, Moesges R, Scadding G, Mullol J, Canonica GW, Munzel U, Demoly P. A new allergic rhinitis therapy (MP29-02*) provides nasal symptom relief days faster than current firstline monotherapies. Allergy 2014; 69: 322-323.

17. Burks AW, Calderon MA, Casale T, Cox L, Demoly P, Jutel M, Nelson H, Akdis CA. Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. Revue Francaise D Allergologie 2014; 54: 66-77.

18. Caillaud D, Horo K, Baiz N, Banerjee S, Charpin D, Lavaud F, de Blay F, Raherison C, Annesi-Maesano I. Exercise-induced bronchospasm related to different phenotypes of rhinitis without asthma in primary schoolchildren: the French Six Cities Study. Clinical and Experimental Allergy 2014; 44: 858-866.

19. Caimmi SME, Manca E, Caimmi D, Marseglia GL, Demoly P. NSAID hypersensitivity in twins. Pediatric Allergy and Immunology 2014; 25: 828-829.

20. Calderon MA, Perreaud J, Demoly P. Inappropriate information on allergy immunotherapy leads to poor acceptance and adherence by patients. Allergy 2014; 69: 607-608.

21. Calderon MA, Rodriguez Del Rio P, Vidal C, Just J, Pfaar O, Linneberg A, Demoly P. An EAACI "European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI)": the methodology. Clinical and translational allergy 2014; 4: 22-22.

22. Carreiro-Martins P, Viegas J, Papoila AL, Aelenei D, Caires I, Araujo-Martins J, Gaspar-Marques J, Cano MM, Mendes AS, Virella D, Rosado-Pinto J, Leiria-Pinto P, Annesi-Maesano I, Neuparth N. CO2 concentration in day care centres is related to wheezing in attending children. European Journal of Pediatrics 2014; 173: 1041-1049.

23. Chaabane N, Annesi-Maesano I, Ramousse O, Caillaud D. Farmers have more respiratory and allergic diseases than farm workers: a cross sectional study among 488 agricultural workers in Auvergne. Allergy 2014; 69: 145-145.

24. Chalhoub B, Denoeud F, Liu S, Parkin IAP, Tang H, Wang X, Chiquet J, Belcram H, Tong C, Samans B, Correa M, Da Silva C, Just J, Falentin C, Koh CS, Le Clainche I, Bernard M, Bento P, Noel B, Labadie K, Alberti A, Charles M, Arnaud D, Guo H, Daviaud C, Alamery S, Jabbari K, Zhao M, Edger PP, Chelaifa H, Tack D, Lassalle G, Mestiri I, Schnel N, Le Paslier M-C, Fan G, Renault V, Bayer PE, Golicz AA, Manoli S, Lee T-H, Vinh Ha Dinh T, Chalabi S, Hu Q, Fan C, Tollenaere R, Lu Y, Battail C, Shen J, Sidebottom CHD, Wang X, Canaguier A, Chauveau A, Berard A, Deniot G, Guan M, Liu Z, Sun F, Lim YP, Lyons E, Town CD, Bancroft I, Wang X, Meng J, Ma J, Pires JC, King GJ, Brunel D, Delourme R, Renard M, Aury J-M, Adams KL, Batley J, Snowdon RJ, Tost J, Edwards D, Zhou Y, Hua W, Sharpe AG, Paterson AH, Guan C, Wincker P. Early allopolyploid evolution in the post-Neolithic Brassica napus oilseed genome. Science 2014; 345: 950-953.

25. Chiriac AM, Demoly P. Drug Allergy Diagnosis. Immunology and Allergy Clinics of North America 2014; 34: 461-+.

26. Crepet A, Papadopoulos A, Elegbede CF, Ait-Dahmane S, Deschildre A, Just J, Bruyere O, Roosen J, Marette S, Moneret-Vautrin DA. MIRABEL: a research program to develop tools for risk and cost/benefit analysis of peanut allergy. Allergy 2014; 69: 63-63.

27. Dainese-Plichon R, Vivinus-Nebot MH, Piche T, Bzioueche-Hadhiri H, Demoly P. Allergic food hypersensitivity in irritable bowel syndrome. Revue Francaise D Allergologie 2014; 54: 529-534.

28. D'Amato G, Cecchi L, D'Amato M, Annesi-Maesano I. Climate change and respiratory diseases. European respiratory review : an official journal of the European Respiratory Society 2014; 23: 161-169.

29. de Silva D, Geromi M, Halken S, Host A, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Cardona V, Dubois AEJ, Poulsen LK, Van Ree R, Vlieg-Boerstra B, Agache I, Grimshaw K, O'Mahony L, Venter C, Arshad SH, Sheikh A, Anaphylaxis EFA. Primary prevention of food allergy in children and adults: systematic review. Allergy 2014; 69: 581-589.

30. de Silva D, Geromi M, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Cardona V, Dubois AEJ, Halken S, Host A, Poulsen LK, Van Ree R, Vlieg-Boerstra BJ, Agache I, Sheikh A, Gui EFAA. Acute and long-term management of food allergy: systematic review. Allergy 2014; 69: 159-167.

31. Deans RM, Gardiner MG, Horne J, Hung AC, Hyland CJT, Just J, Smith JA, Yin J. Isolation and Characterization of 1 beta-Acetoxypolygodial from Tasmannia lanceolata. Asian Journal of Organic Chemistry 2014; 3: 1193-1196.

32. Demoly P. Drug Hypersensitivity Preface. Immunology and Allergy Clinics of North America 2014; 34: XV-XVI.

33. Demoly P, Adkinson NF, Brockow K, Castells M, Chiriac AM, Greenberger PA, Khan DA, Lang DM, Park HS, Pichler W, Sanchez-Borges M, Shiohara T, Thong BYH. International Consensus on drug allergy. Allergy 2014; 69: 420-437.

34. Demoly P, Andre C. Information and Consent Forms for Sublingual and Oral Allergen Immunotherapy. 2014.

35. Demoly P, Bourg F, Tauleigne L, Fraser DM, Calderon MA. The impact of physician-patient communication on the prescription and perception of allergen immunotherapy. Allergy 2014; 69: 511-511.

36. Demoly P, Chiriac AM, Berge B, Rostin M. Reasons for prescribing second generation antihistamines to treat allergic rhinitis in real-life conditions and patient response. Allergy Asthma and Clinical Immunology 2014; 10.

37. Demoly P, Decot E, Lozovskis V, Rehm D, Tommerup L, Kleine-Tebbe J. Effective treatment of house dust mite (HDM) allergic rhinitis with the SQ HDM SLIT-tablet; results from a DBPC phase III trial (MERIT). Allergy 2014; 69: 183-183.

38. Demoly P, Hagedoorn P, de Boer AH, Frijlink HW. The clinical relevance of dry powder inhaler performance for drug delivery. Respiratory Medicine 2014; 108: 1195-1203.

39. Demoly P, Rossi O, Matucci A, David M, Vidal Pan C. Profile of patients with severe respiratory allergies to house dust mite (HDMs) allergens: a survey in three European countries. Allergy 2014; 69: 588-588.

40. Demoly P, Tanno LK, Akdis CA, Lau S, Calderon MA, Santos AF, Sanchez-Borges M, Rosenwasser LJ, Pawankar R, Papadopoulos NG. Global classification and coding of hypersensitivity diseases - An EAACI - WAO survey, strategic paper and review. Allergy 2014; 69: 559-570.

41. Deschildre A, Moneret-Vautrin DA, Just J, Papadopoulos A, Bruyere O, Elegbede CF, Crepet A. MIRABEL project: description of a French pediatric population of 680 peanut allergic children (part 1). Allergy 2014; 69: 177-177.

42. Deschildre A, Villard-Truc F, Gomez SA, Santos C, Just J, Bidat E, de Boissieu D, Bourrier T, Bouvier M, Chabert AB, Couderc L, Doyen V, Dassonval CF, Hoppe A, Jubin V, Kassmann K, Morisset M, Villain AC, Grp Travail Allergie A. Emergency action plan in children's food allergy: Position paper of the interest group for food allergy of the French Allergy Society. Revue Francaise D Allergologie 2014; 54: 389-393.

43. Devillier P, Dreyfus JF, Demoly P, Calderon M. A comparison of the relative clinical impacts of sublingual allergen immunotherapy tablets and symptomatic drugs in grass-pollen-induced allergic rhinoconjunctivitis. Allergy 2014; 69: 510-510.

44. Devillier P, Dreyfus J-F, Demoly P, Calderon MA. A meta-analysis of sublingual allergen immunotherapy and pharmacotherapy in pollen-induced seasonal allergic rhinoconjunctivitis. Bmc Medicine 2014; 12.

45. Dhami S, Panesar SS, Roberts G, Muraro A, Worm M, Bilo MB, Cardona V, Dubois AEJ, DunnGalvin A, Eigenmann P, Fernandez-Rivas M, Halken S, Lack G, Niggemann B, Rueff F, Santos AF, Vlieg-Boerstra B, Zolkipli ZQ, Sheikh A, Allergy EF. Management of anaphylaxis: a systematic review. Allergy 2014; 69: 168-175.

46. Diouf I, Botton J, Charles MA, Morel O, Forhan A, Kaminski M, Heude B, Grp ES. Specific role of maternal weight change in the first trimester of pregnancy on birth size. Maternal and Child Nutrition 2014; 10: 315-326.

47. Dizier M-H, Margaritte-Jeannin P, Madore A-M, Moffatt M, Brossard M, Lavielle N, Sarnowski C, Just J, Cookson W, Lathrop M, Laprise C, Bouzigon E, Demenais F. The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype. Journal of Allergy and Clinical Immunology 2014; 134: 576-+.

48. Elegbede CF, Papadopoulos A, Deschildre A, Bruyere O, Just J, Moneret-Vautrin DA, Crepet A. Mirabel project: introducing covariables in the modelling of threshold doses for French peanut-allergic patients. Allergy 2014; 69: 164-164.

49. Farah W, Nakhle MM, Abboud M, Annesi-Maesano I, Zaarour R, Saliba N, Germanos G, Gerard J. Time series analysis of air pollutants in Beirut, Lebanon. Environmental Monitoring and Assessment 2014; 186: 8203-8213.

50. Fuertes E, Butland BK, Anderson HR, Carlsten C, Strachan DP, Brauer M, Grp IPTS. Childhood intermittent and persistent rhinitis prevalence and climate and vegetation: a global ecologic analysis. Annals of Allergy Asthma & Immunology 2014; 113: 386-U388.

51. Haahtela T, Burbach GJ, Bachert C, Bindslev-Jensen C, Bonini S, Bousquet J, Bousquet-Rouanet L, Bousquet PJ, Bresciani M, Bruno A, Canonica GW, Darsow U, Demoly P, Durham SR, Fokkens WJ, Giavi S, Gjomarkaj M, Gramiccioni C, Kowalski ML, Losonczy G, Orosz M, Papadopoulos NG, Stingl G, Todo-Bom A, von Mutius E, Koehli A, Woehrl S, Jarvenpaa S, Kautiainen H, Petman L, Selroos O, Zuberbier T, Heinzerling LM. Clinical relevance is associated with allergen-specific wheal size in skin prick testing. Clinical and Experimental Allergy 2014; 44: 407-416.

52. Hohmann C, Pinart M, Tischer C, Gehring U, Heinrich J, Kull I, Melen E, Smit HA, Torrent M, Wijga AH, Wickman M, Bachert C, Carlsen KCL, Carlsen K-H, Bindslev-Jensen C, Eller E, Esplugues A, Fantini MP, Annesi-Maesano I, Momas I, Porta D, Vassilaki M, Waiblinger D, Sunyer J, Anto JM, Bousquet J, Keil T, Me DSG. The Development of the MeDALL Core Questionnaires for a Harmonized Follow-Up Assessment of Eleven European Birth Cohorts on Asthma and Allergies. International Archives of Allergy and Immunology 2014; 163: 215-224.

53. Just J, Amat F. Other treatments for allergic asthma. Revue Francaise D Allergologie 2014; 54: 96-100.

54. Just J, Deslandes-Boutmy E, Amat F, Desseaux K, Nemni A, Bourrat E, Sahraoui F, Panse I, Bagot M, Fouere S. Natural history of allergic sensitization in infants with early-onset atopic dermatitis: results from ORCA Study. Pediatric Allergy and Immunology 2014; 25: 668-673.

55. Just J, Saint-Pierre P, Gouvis-Echraghi R, Laoudi Y, Roufai L, Momas I, Maesano IA. Childhood Allergic Asthma Is Not a Single Phenotype. Journal of Pediatrics 2014; 164: 815-820.

56. Lambert N, Guiddir T, Amat F, Just J. Pre-treatment by omalizumab allows allergen immunotherapy in children and young adults with severe allergic asthma. Pediatric Allergy and Immunology 2014; 25: 829-832.

57. Leonardi A, Bogacka E, Fauquert JL, Kowalski ML, Groblewska A, Jedrzejczak-Czechowicz M, Doan S, Marmouz F, Demoly P, Delgado L. Recognizing and diagnosing hypersensitivity disorders of the ocular surface. Revue Francaise D Allergologie 2014; 54: 377-388.

58. Leoni MC, Demoly MP, Chiriac AM, Marseglia GL, Demoly P. PD24 - Oral food challenges to peanut in the pediatric population at the Allergy Department of the University Hospital of Montpellier, France. Clinical and translational allergy 2014; 4: P24-P24.

59. Macchiaverni P, Rekima A, Turfkruyer M, Mascarell L, Airouche S, Moingeon P, Adel-Patient K, Condino-Neto A, Annesi-Maesano I, Prescott SL, Tulic MK, Verhasselt V. Respiratory allergen from house dust mite is present in human milk and primes for allergic sensitization in a mouse model of asthma. Allergy 2014; 69: 395-398.

60. Macchiaverni P, Rekima A, Turfkruyer M, Mascarell L, Airouche S, Moingeon P, Adel-Patient K, Condino-Neto A, Annesi-Maesano I, Prescott SL, Tulic MK, Verhasselt V. PD01 - Respiratory allergens in human milk: potential impact on susceptibility to allergic airway disease. Clinical and translational allergy 2014; 4: P1-P1.

61. Michaud B, Aroulandom J, Baiz N, Amat F, Gouvis-Echraghi R, Candon S, Couderc R, Bach J-F, Chatenoud L, Just J. Analyzing Casein-Specific IL-4 and IL-13 Secreting T-Cells: A Reliable Tool For Diagnosis Of Cow's Milk Allergy. Journal of Allergy and Clinical Immunology 2014; 133: AB234-AB234.

62. Michaud B, Aroulandom J, Baiz N, Amat F, Gouvis-Echraghi R, Candon S, Foray AP, Couderc R, Bach JF, Chatenoud L, Just J. Casein-specific I1-4- and IL-13-secreting T cells: a tool to implement diagnosis of cow's milk allergy. Allergy 2014; 69: 1473-1480.

63. Michaud B, Gouvis-Echraghi R, Candon S, Couderc R, Jais JP, Bach JF, Chatenoud L, Just J. Quantification of circulating house dust mite-specific IL-4-and IL-13-secreting T cells correlates with rhinitis severity in asthmatic children and varies with the seasons. Clinical and Experimental Allergy 2014; 44: 222-230.

64. Moussu L, Saint-Pierre P, Panayotopoulos V, Couderc R, Amat F, Just J. Determinants of Allergic Rhinitis in Young Children with Asthma. Plos One 2014; 9.

65. Muraro A, Roberts G, Worm M, Bilo MB, Brockow K, Fernandez Rivas M, Santos AF, Zolkipli ZQ, Bellou A, Beyer K, Bindslev-Jensen C, Cardona V, Clark AT, Demoly P, Dubois AEJ, DunnGalvin A, Eigenmann P, Halken S, Harada L, Lack G, Jutel M, Niggemann B, Rueff F, Timmermans F, Vlieg-Boerstra BJ, Werfel T, Dhami S, Panesar S, Akdis CA, Sheikh A, Anaphylaxis EFA. Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology. Allergy 2014; 69: 1026-1045.

66. Nardini S, Annesi-Maesano I, Del Donno M, Delucchi M, Bettoncelli G, Lamberti V, Patera C, Polverino M, Russo A, Santoriello C, Soverina P. The AIMAR recommendations for early diagnosis of chronic obstructive respiratory disease based on the WHO/GARD model*. Multidisciplinary respiratory medicine 2014; 9: 46-46.

67. Nieto A, Wahn U, Bufe A, Eigenmann P, Halken S, Hedlin G, Host A, Hourihane J, Just J, Lack G, Lau S, Matricardi PM, Muraro A, Papadopoulos N, Roberts G, Simpson A, Valovirta E, Weidinger S, Wickman M, Mazon A. Allergy and asthma prevention 2014. Pediatric Allergy and Immunology 2014; 25: 516-533.

68. Pfaar O, Demoly P, van Wijk RG, Bonini S, Bousquet J, Canonica GW, Durham SR, Jacobsen L, Malling HJ, Moesges R, Papadopoulos NG, Rak S, Rodriguez del Rio P, Valovirta E, Wahn U, Calderon MA. Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper. Allergy 2014; 69: 854-867.

69. Pinart M, Benet M, Annesi-Maesano I, von Berg A, Berdel D, Carlsen KCL, Carlsen K-H, Bindslev-Jensen C, Eller E, Fantini MP, Lenzi J, Gehring U, Heinrich J, Hohmann C, Just J, Keil T, Kerkhof M, Kogevinas M, Koletzko S, Koppelman GH, Kull I, Lau S, Meien E, Mamas I, Porta D, Postma D, Ranciere F, Smit HA, Stein RT, Tischer CG, Torrent M, Wickman M, Wijga AH, Bouquest J, Sunyer J, Basagaina X, Guerra S, Garcia-Aymerich J, Anto JM. Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study. Lancet Respiratory Medicine 2014; 2: 131-140.

70. Pitsios C, Rodriguez del Rio PA, Demoly P, Pfaar O, Tsoumani M, Valovirta E, Paraskevopoulos G, Rueff F, Gawlik R, Sturm G, Bilo BM, Calderon M. CONtraindications to Specific ImmunoTherapy (CONSIT) survey. Allergy 2014; 69: 509-510.

71. Raulf M, Buters J, Chapman M, Cecchi L, de Blay F, Doekes G, Eduard W, Heederik D, Jeebhay MF, Kespohl S, Krop E, Moscato G, Pala G, Quirce S, Sander I, Schlunssen V, Sigsgaard T, Walusiak-Skorupa J, Wiszniewska M, Wouters IM, Annesi-Maesano I. Monitoring of occupational and environmental aeroallergens - EAACI Position Paper Concerted action of the EAACI IG Occupational Allergy and Aerobiology & Air Pollution. Allergy 2014; 69: 1280-1299.

72. Reitter M, Petitpain N, Latarche C, Cottin J, Massy N, Demoly P, Gillet P, Mertes PM, French Network of Regional Pharmacovigilance C. Fatal anaphylaxis with neuromuscular blocking agents: a risk factor and management analysis. Allergy 2014; 69: 954-959.

73. Rodriguez del Rio P, Vidal C, Just J, Pfaar O, Demoly P, Calderon M. Interim analysis of the European survey on adverse systemic reactions due to allergen immunotherapy (EASSI): doctor and patient's profile. Allergy 2014; 69: 610-611.

74. Saadeh D, Salameh P, Caillaud D, Charpin D, de Blay F, Kopferschmitt C, Lavaud F, Annesi-Maesano I, Baldi I, Raherison C. High body mass index and allergies in schoolchildren: the French six cities study. BMJ open respiratory research 2014; 1: e000054-e000054.

75. Schrijvers R, Ahmedali Y, Chiriac AM, Demoly P. Negative predictive value of skin testing for iodinated contrast media allergy. Allergy 2014; 69: 260-261.

76. Simoni M, Annesi-Maesano I, Viegi G. Indoor air pollution. In: AnnesiMaesano I, Lundback B, Viegi G, Welte T, editors. Respiratory Epidemiology; 2014. p. 198-210.

77. Sonnenschein-van der Voort AMM, Arends LR, de Jongste JC, Annesi-Maesano I, Arshad SH, Barros H, Basterrechea M, Bisgaard H, Chatzi L, Corpeleijn E, Correia S, Craig LC, Devereux G, Dogaru C, Dostal M, Duchen K, Eggesbo M, van der Ent CK, Fantini MP, Forastiere F, Frey U, Gehring U, Gori D, van der Gugten AC, Hanke W, Henderson AJ, Heude B, Iniguez C, Inskip HM, Keil T, Kelleher CC, Kogevinas M, Kreiner-Moller E, Kuehni CE, Kupers LK, Lancz K, Larsen PS, Lau S, Ludvigsson J, Mommers M, Nybo Andersen A-M, Palkovicova L, Pike KC, Pizzi C, Polanska K, Porta D, Richiardi L, Roberts G, Schmidt A, Sram RJ, Sunyer J, Thijs C, Torrent M, Viljoen K, Wijga AH, Vrijheid M, Jaddoe VWV, Duijts L. Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children. The Journal of allergy and clinical immunology 2014; 133: 1317-1329.

78. Tanno LK, Calderon MA, Goldberg BJ, Akdis CA, Papadopoulos NG, Demoly P. Categorization of allergic disorders in the new World Health Organization International Classification of Diseases. Clinical and translational allergy 2014; 4: 42-42.

79. Trebuchon F, Lheritier-Barrand M, David M, Demoly P. Characteristics and management of sublingual allergen immunotherapy in children with allergic rhinitis and asthma induced by house dust mite allergens. Clinical and translational allergy 2014; 4: 15-15.

80. Valeyre D, Duchemann B, Nunes H, Uzunhan Y, Annesi-Maesano I. Interstitial lung diseases. In: AnnesiMaesano I, Lundback B, Viegi G, Welte T, editors. Respiratory Epidemiology; 2014. p. 79-87.

81. Vidal C, Rodriguez del Rio P, Pfaar O, Just J, Demoly P, Calderon M. Interim analysis of the European survey on adverse systemic reactions due to allergen immunotherapy (EASSI): patient's systemic reactions. Allergy 2014; 69: 614-615.

82. Wang Y, Zhu R, Liu G, Li W, Chen H, Daures J-P, Chiriac AM, Demoly P. Prevalence of uncontrolled allergic rhinitis in Wuhan, China: A prospective cohort study. American Journal of Rhinology & Allergy 2014; 28: 397-403.

83. Weinmayr G, Forastiere F, Buechele G, Jaensch A, Strachan DP, Nagel G, Grp IPTS. Overweight/Obesity and Respiratory and Allergic Disease in Children: International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two. Plos One 2014; 9.

84. Youssouf H, Liousse C, Roblou L, Assamoi EM, Salonen RO, Maesano C, Banerjee S, Annesi-Maesano I, Study P. Quantifying wildfires exposure for investigating health-related effects. Atmospheric Environment 2014; 97: 239-251.

85. Youssouf H, Liousse C, Roblou L, Assamoi E-M, Salonen RO, Maesano C, Banerjee S, Annesi-Maesano I. Non-Accidental Health Impacts of Wildfire Smoke. International Journal of Environmental Research and Public Health 2014; 11: 11772-11804.