• Équipe EPAR

    L'équipe "Épidémiologie des maladies Allergiques et Respiratoires" est intégrée à l'Unité INSERM UMR-S 1136, Institut Pierre Louis d'Epidémiologie et Santé Publique, regroupe 6 Group Leaders, 12 chercheurs ou enseignants chercheurs,2 personnels techno-administratifs, 3 doctorants et 1 post-doc.

  • Les maladies allergiques et respiratoires

    touchent une partie importante de la population et on leur associe des coûts sociaux et économiques importants. Depuis quelques décennies, la prévalence de ces affections n'a cessé d'augmenter. Les causes et les mécanismes de cet accroissement n'ont pas encore été élucidés. Les travaux menés par l'équipe d'EPidémiologie des maladies Allergiques et Respiratoires (EPAR) ont pour but d'approfondir la recherche étiologique des principales maladies allergiques et respiratoires (rhinite, asthme, BPCO, cancer du poumon...), d'identifier les sujets à risque, et de déterminer les coûts associés. L'hypothèse à la base de ces recherches est que l'augmentation des maladies allergiques et respiratoires est due à la fois à des changements de type environnemental et à des modifications de la « sensibilité » de l'hôte. Dans ce contexte, les facteurs de risque, de susceptibilité et de vulnérabilité sont identifiés.

  • Les axes de recherche

    Les principaux axes de recherche qui vont être développés dans les années à venir sont :

    • Impact de la pollution atmosphérique sur les maladies allergiques et respiratoires.
    • Événements de la vie précoce et développement des maladies allergiques et respiratoires.
    • Dossiers patients via le web (e-BPCO, e-Muco, e-dev...).

    Isabella Annesi-Maesano
    Directeur de Recherche INSERM
  • 1
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Bienvenue sur le site de l'équipe EPAR

1. Schrijvers R, Lagara K, Breynaert C, Demoly P, Chiriac AM. Drug hypersensitivity workup for suspected pristinamycin drug hypersensitivity. J Allergy Clin Immunol Pract. 2016 Jun 8. pii: S2213-2198(16)30120-9. doi:10.1016/j.jaip.2016.04.010. [Epub ahead of print] PubMed PMID: 27289495.

2. Bousquet J, Schünemann HJ, Hellings PW, Arnavielhe S, Bachert C, Bedbrook A, Bergmann KC, Bosnic-Anticevich S, Brozek J, Calderon M, Canonica GW, Casale TB, Chavannes NH, Cox L, Chrystyn H, Cruz AA, Dahl R, De Carlo G, Demoly P, Devillier P, Dray G, Fletcher M, Fokkens WJ, Fonseca J, Gonzalez-Diaz SN, Grouse L, Keil T, Kuna P, Larenas-Linnemann D, Lodrup Carlsen KC, Meltzer EO, Mullol J, Muraro A, Naclerio RN, Palkonen S, Papadopoulos NG, Passalacqua G, Price D, Ryan D, Samolinski B, Scadding GK, Sheikh A, Valiulis A, Valovirta E, Walker S, Wickman M, Yorgancioglu A, Zuberbier T; MASK study group*. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis. J Allergy Clin Immunol. 2016 Apr 23. pii: S0091-6749(16)30148-8. doi: 10.1016/j.jaci.2016.03.025. [Epub ahead of print] PubMed PMID: 27260321.

3. Tanno LK, Calderon MA, Papadopoulos NG, Sanchez-Borges M, Moon HB, Sisul JC, Jares EJ, Sublett JL, Casale T, Demoly P; Joint Allergy Academies. Surveying the new allergic and hypersensitivity conditions chapter of the International classification of diseases (ICD)-11. Allergy. 2016 Jun 2. doi: 10.1111/all.12945. [Epub ahead of print] PubMed PMID: 27253871.

4. Chiriac AM, Demoly P. [Allergy to neuromuscular blocking agents]. Presse Med. 2016 May 24. pii: S0755-4982(16)30049-5. doi: 10.1016/j.lpm.2016.02.023. [Epub ahead of print] French. PubMed PMID: 27234905.

5. Demoly P, Kleine-Tebbe J. Reply. J Allergy Clin Immunol. 2016 May 24. pii: S0091-6749(16)30198-1. doi: 10.1016/j.jaci.2016.03.034. [Epub ahead of print] PubMed PMID: 27233151.

6. Passalacqua G, Sastre J, Pfaar O, Wahn U, Demoly P. Comparison of allergenic extracts from different origins: the value of the FDA's bioequivalent allergy unit (BAU). Expert Rev Clin Immunol. 2016 May 30:1-7. [Epub ahead of print] PubMed PMID: 27215895.

7. Demoly P, Matucci A, Rossi O, Vidal C. "A year-long, fortnightly, observational survey in three European countries of patients with respiratory allergies induced by house dust mites: Methodology, demographics and clinical characteristics". BMC Pulm Med. 2016 May 23;16(1):85. doi: 10.1186/s12890-016-0246-9. PubMed PMID: 27215208; PubMed Central PMCID: PMC4877752.

8. Nahas O, Nkashama-Tshiaba L, Demoly P, Chiriac AM. Anaphylaxis case report to trimethylphloroglucinol (Spasfon(®)). Allergol Int. 2016 May 14. pii: S1323-8930(16)30041-7. doi: 10.1016/j.alit.2016.04.004. [Epub ahead of print] PubMed PMID: 27189530.

9. Cousin M, Chiriac A, Molinari N, Demoly P, Caimmi D. Phenotypical characterization of children with hypersensitivity reactions to NSAIDs. Pediatr Allergy Immunol. 2016 May 12. doi: 10.1111/pai.12596. [Epub ahead of print] PubMed PMID: 27171669.

10. Brockow K, Aberer W, Atanaskovic-Markovic M, Bavbek S, Bircher A, Bilo B, Blanca M, Bonadonna P, Burbach G, Calogiuri G, Caruso C, Celik G, Cernadas J, Chiriac A, Demoly P, Oude Elberink JN, Fernandez J, Gomes E, Garvey LH, Gooi J, Gotua M, Grosber M, Kauppi P, Kvedariene V, Laguna JJ, Makoswska J, Mosbech H, Nakonechna A, Papadopolous NG, Ring J, Romano A, Rockmann H, Sargur R, Sedlackova L, Sigurdardottir S, Schnyder B, Storaas T, Torres M, Zidarn M, Terreehorst I. Drug allergy passport and other documentation for patients with drug hypersensitivity - An ENDA/EAACI Drug Allergy Interest Group Position Paper. Allergy. 2016 May 4. doi: 10.1111/all.12929. [Epub ahead of print] PubMed PMID: 27145347.

11. Tanno LK, Calderon MA, Demoly P; Joint Allergy Academies. New Allergic and Hypersensitivity Conditions Section in the International Classification of Diseases-11. Allergy Asthma Immunol Res. 2016 Jul;8(4):383-8. doi: 10.4168/aair.2016.8.4.383. PubMed PMID: 27126732; PubMed Central PMCID: PMC4853516.

12. Tanno LK, Calderon MA, Li J, Casale T, Demoly P; Joint Allergy Academies. Updating Allergy and/or Hypersensitivity Diagnostic Procedures in the WHO ICD-11 Revision. J Allergy Clin Immunol Pract. 2016 Apr 20. pii: S2213-2198(16)00050-7. doi: 10.1016/j.jaip.2016.01.015. [Epub ahead of print] Review. PubMed PMID: 27107691.

13. Cox LS, Didier A, Demoly P, Wahn U, Pradalier A, Frew AJ, Devillier P. Methodological aspects of a meta-analysis of grass pollen allergen sublingual immunotherapy tablets. J Allergy Clin Immunol. 2016 Apr 12. pii: S0091-6749(16)00365-1. doi: 10.1016/j.jaci.2016.01.039. [Epub ahead of print] PubMed PMID: 27084407.

14. Demoly P, Broué-Chabbert A, Wessel F, Chartier A. Severity and disease control before house dust mite immunotherapy initiation: ANTARES a French observational survey. Allergy Asthma Clin Immunol. 2016 Apr 11;12:13. doi: 10.1186/s13223-016-0119-z. eCollection 2016. PubMed PMID: 27069487; PubMed Central PMCID: PMC4827229.

15. Dhami S, Nurmatov U, Roberts G, Pfaar O, Muraro A, Ansotegui IJ, Calderon M, Cingi C, Demoly P, Durham S, van Wijk RG, Halken S, Hamelmann E, Hellings P, Jacobsen L, Knol E, Linnemann DL, Lin S, Maggina V, Oude-Elberink H, Pajno G, Panwankar R, Pastorello E, Pitsios C, Rotiroti G, Timmermans F, Tsilochristou O, Varga EM, Wilkinson J, Williams A, Worm M, Zhang L, Sheikh A. Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review. Clin Transl Allergy. 2016 Mar 22;6:12. doi: 10.1186/s13601-016-0099-6. eCollection 2016. PubMed PMID: 27006751; PubMed Central PMCID: PMC4802892.

16. Mayorga C, Celik G, Rouzaire P, Whitaker P, Bonadonna P, Cernadas JR, Vultaggio A, Brockow K, Caubet JC, Makowska J, Nakonechna A, Romano A, Montañez MI, Laguna JJ, Zanoni G, Gueant JL, Oude Elberink H, Fernandez J, Viel S, Demoly P, Torres MJ; In vitro tests for Drug Allergy Task Force of EAACI Drug Interest Group. In vitro tests for Drug Hypersensitivity Reactions. An ENDA/EAACI Drug Allergy Interest Group Position Paper. Allergy. 2016 Mar 17. doi: 10.1111/all.12886. [Epub ahead of print] PubMed PMID: 26991315.

17. Bousquet J, Anto JM, Akdis M, Auffray C, Keil T, Momas I, Postma D, Valenta R, Wickman M, Cambon-Thomsen A, Haahtela T, Lambrecht BN, Lodrup-Carlsen K, Koppelman GH, Sunyer J, Zuberbier T, Annesi-Maesano I, Arno A, Bindslev-Jensen C, De Carlo G, Forastiere F, Heinrich J, Kowalski ML, Maier D, Melén E, Palkonen S, Smit HA, Standl M, Wright J, Arsanoj A, Benet M, Balardini N, Garcia-Aymerich J, Gehring U, Guerra S, Hohman C, Kull I, Lupinek C, Pinart M, Skrindo I, Westman M, Smagghe D, Akdis C, Albang R, Anastasova V, Anderson N, Bachert C, Ballereau S, Ballester F, Basagana X, Bedbrook A, Bergstrom A, von Berg A, Brunekreef B, Burte E, Carlsen KH, Chatzi L, Coquet JM, Curin M, Demoly P, Eller E, Fantini MP, Gerhard B, Hammad H, von Hertzen L, Hovland V, Jacquemin B, Just J, Keller T, Kerkhof M, Kiss R, Kogevinas M, Koletzko S, Lau S, Lehmann I, Lemonnier N, McEachan R, Mäkelä M, Mestres J, Minina E, Mowinckel P, Nadif R, Nawijn M, Oddie S, Pellet J, Pin I, Porta D, Rancière F, Rial-Sebbag A, Saes Y, Schuijs MJ, Siroux V, Tischer CG, Torrent M, Varraso R, De Vocht J, Wenger K, Wieser S, Xu C. Paving the way of systems biology and precision medicine in allergic diseases: The MeDALL success story. Allergy. 2016 Mar 10. doi: 10.1111/all.12880. [Epub ahead of print] Review. PubMed PMID: 26970340.

18. Tanno LK, Calderon MA, Papadopoulos NG, Sanchez-Borges M, Rosenwasser LJ, Bousquet J, Pawankar R, Sisul JC, Cepeda AM, Li J, Muraro A, Fineman S, Sublett JL, Katelaris CH, Chang YS, Moon HB, Casale T, Demoly P; Joint Allergy Academies. Revisiting Desensitization and Allergen Immunotherapy Concepts for the International Classification of Diseases (ICD)-11. J Allergy Clin Immunol Pract. 2016 Mar 8. pii: S2213-2198(16)00021-0. doi: 10.1016/j.jaip.2015.12.022. [Epub ahead of print] Review. PubMed PMID: 26969269.

19. Devillier P, Bousquet PJ, Grassin-Delyle S, Salvator H, Demoly P, Bousquet J, de Beaumont O. Comparison of outcome measures in allergic rhinitis in children, adolescents and adults. Pediatr Allergy Immunol. 2016 Jun;27(4):375-81. doi: 10.1111/pai.12561. PubMed PMID: 26949928.

20. Chiron R, Caimmi D, Valiulis A, Durieu I, Tejedor P, Le Cam Y, Boudes M, Jonquet O, Strandberg T, Michel JP, de Manuel Keenoy E, Demoly P, Mercier J, Bourret R, Bousquet J; MACVIA-LR European Innovation Partnership on Active and Healthy Ageing Reference Site. A model for active and healthy ageing with a rare genetic disease: cystic fibrosis. Eur Respir J. 2016 Mar;47(3):714-9. doi: 10.1183/13993003.01237-2015. PubMed PMID: 26929314.

21. Dhami S, Nurmatov U, Agache I, Lau S, Muraro A, Jutel M, Roberts G, Akdis C, Bonini M, Calderon M, Casale T, Cavkaytar O, Cox L, Demoly P, Flood B, Hamelmann E, Izuhara K, Kalayci Ö, Kleine-Tebbe J, Nieto A, Papadopoulos N, Pfaar O, Rosenwasser L, Ryan D, Schmidt-Weber C, Szefler S, Wahn U, van Wijk RG, Wilkinson J, Sheikh A. Allergen immunotherapy for allergic asthma: protocol for a systematic review. Clin Transl Allergy. 2016 Feb 9;6:5. doi: 10.1186/s13601-016-0094-y. eCollection 2015. PubMed PMID: 26862389; PubMed Central PMCID: PMC4746770.

22. Jutel M, Agache I, Bonini S, Burks AW, Calderon M, Canonica W, Cox L, Demoly P, Frew AJ, O'Hehir R, Kleine-Tebbe J, Muraro A, Lack G, Larenas D, Levin M, Martin BL, Nelson H, Pawankar R, Pfaar O, van Ree R, Sampson H, Sublett JL, Sugita K, Du Toit G, Werfel T, Gerth van Wijk R, Zhang L, Akdis M, Akdis CA. International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics. J Allergy Clin Immunol. 2016 Feb;137(2):358-68. doi: 10.1016/j.jaci.2015.12.1300. Review. PubMed PMID: 26853128.

23. Klimek L, Demoly P, Price D. Effectiveness of allergic rhinitis treatments in real-life with a focus on MP-AzeFlu. Expert Rev Clin Pharmacol. 2016 May;9(5):705-14. doi: 10.1586/17512433.2016.1148598. Epub 2016 Feb 27. PubMed PMID: 26839083.

24. Klimek L, Mosbech H, Zieglmayer P, Rehm D, Stage BS, Demoly P. SQ house dust mite (HDM) SLIT-tablet provides clinical improvement in HDM-induced allergic rhinitis. Expert Rev Clin Immunol. 2016 Apr;12(4):369-77. doi: 10.1586/1744666X.2016.1144473. Epub 2016 Feb 11. PubMed PMID: 26788764.

25. Demoly P, Passalacqua G, Pfaar O, Sastre J, Wahn U. Management of the polyallergic patient with allergy immunotherapy: a practice-based approach. Allergy Asthma Clin Immunol. 2016 Jan 11;12:2. doi: 10.1186/s13223-015-0109-6. eCollection 2016. Review. PubMed PMID: 26759555; PubMed Central PMCID: PMC4709898.

26. Tanno LK, Calderon MA, Demoly P; Allergy Academies. Optimization and simplification of the Allergic and Hypersensitivity conditions classification for the ICD-11. Allergy. 2016 May;71(5):671-6. doi: 10.1111/all.12834. Epub 2016 Jan 26. PubMed PMID: 26728868.

27. Oussalah A, Mayorga C, Blanca M, Barbaud A, Nakonechna A, Cernadas J, Gotua M, Brockow K, Caubet JC, Bircher A, Atanaskovic M, Demoly P, K Tanno L, Terreehorst I, Laguna JJ, Romano A, Guéant JL; Task force ‘Genetic predictors of drug hypersensitivity’ of the European Network on Drug Allergy (ENDA) of EAACI. Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review. Allergy. 2016 Apr;71(4):443-62. doi: 10.1111/all.12821. Epub 2016 Jan 29. Review. PubMed PMID: 26678823.

28. Caimmi D, Calderon MA, Bousquet J, Demoly P. Allergen Immunotherapy Outcomes and Unmet Needs: A Critical Review. Immunol Allergy Clin North Am. 2016 Feb;36(1):181-9. doi: 10.1016/j.iac.2015.08.011. Review. PubMed PMID: 26617234.

29. Amaral AF, Newson RB, Abramson MJ, Antó JM, Bono R, Corsico AG, de Marco R, Demoly P, Forsberg B, Gislason T, Heinrich J, Huerta I, Janson C, Jõgi R, Kim JL, Maldonado J, Martinez-Moratalla Rovira J, Neukirch C, Nowak D, Pin I, Probst-Hensch N, Raherison-Semjen C, Svanes C, Urrutia Landa I, van Ree R, Versteeg SA, Weyler J, Zock JP, Burney PG, Jarvis DL. Changes in IgE sensitization and total IgE levels over 20 years of follow-up. J Allergy Clin Immunol. 2016 Jun;137(6):1788-1795.e9. doi: 10.1016/j.jaci.2015.09.037. Epub 2015 Nov 14. PubMed PMID: 26586040; PubMed Central PMCID: PMC4889785.

30. Demoly P, Emminger W, Rehm D, Backer V, Tommerup L, Kleine-Tebbe J. Effective treatment of house dust mite-induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet: Results from a randomized, double-blind, placebo-controlled phase III trial. J Allergy Clin Immunol. 2016 Feb;137(2):444-451.e8. doi: 10.1016/j.jaci.2015.06.036. Epub 2015 Aug 17. PubMed PMID: 26292778.

31. Soumagne T, Laveneziana P, Veil-Picard M, Guillien A, Claudé F, Puyraveau M, Annesi-Maesano I, Roche N, Dalphin JC, Degano B. Asymptomatic subjects with airway obstruction have significant impairment at exercise. Thorax. 2016 May 25. pii: thoraxjnl-2015-207953. doi: 10.1136/thoraxjnl-2015-207953. [Epub ahead of print] PubMed PMID: 27226423.

32. Charpin D, Pairon JC, Annesi-Maesano I, Caillaud D, de Blay F, Dixsaut G, Housset B, Meurice JC, Roussel I, Zmirou D, Delaval P, Dalphin JC; groupe

pathologies pulmonaires professionnelles environnementales et iatrogéniques

(PAPPEI) et le conseil scientifique de la Société de pneumologie de langue

française (SPLF). [Outdoor pollution and its effects on lung health. Expert

document from the groupe pathologies pulmonaires professionnelles

environnementales et iatrogéniques (PAPPEI) of the Société de pneumologie de

langue française (SPLF)]. Rev Mal Respir. 2016 May 19. pii:

S0761-8425(16)30038-9. doi: 10.1016/j.rmr.2016.04.002. [Epub ahead of print]

French. PubMed PMID: 27209117.

33: Annesi-Maesano I, Dinh-Xuan AT. Is exhaled nitric oxide a marker of air

pollution effect? Eur Respir J. 2016 May;47(5):1304-6. doi:

10.1183/13993003.00521-2016. PubMed PMID: 27132258.

34: Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, Reese SE,

Markunas CA, Richmond RC, Xu CJ, Küpers LK, Oh SS, Hoyo C, Gruzieva O, Söderhäll

C, Salas LA, Baïz N, Zhang H, Lepeule J, Ruiz C, Ligthart S, Wang T, Taylor JA,

Duijts L, Sharp GC, Jankipersadsing SA, Nilsen RM, Vaez A, Fallin MD, Hu D,

Litonjua AA, Fuemmeler BF, Huen K, Kere J, Kull I, Munthe-Kaas MC, Gehring U,

Bustamante M, Saurel-Coubizolles MJ, Quraishi BM, Ren J, Tost J, Gonzalez JR,

Peters MJ, Håberg SE, Xu Z, van Meurs JB, Gaunt TR, Kerkhof M, Corpeleijn E,

Feinberg AP, Eng C, Baccarelli AA, Benjamin Neelon SE, Bradman A, Merid SK,

Bergström A, Herceg Z, Hernandez-Vargas H, Brunekreef B, Pinart M, Heude B, Ewart

S, Yao J, Lemonnier N, Franco OH, Wu MC, Hofman A, McArdle W, Van der Vlies P,

Falahi F, Gillman MW, Barcellos LF, Kumar A, Wickman M, Guerra S, Charles MA,

Holloway J, Auffray C, Tiemeier HW, Smith GD, Postma D, Hivert MF, Eskenazi B,

Vrijheid M, Arshad H, Antó JM, Dehghan A, Karmaus W, Annesi-Maesano I, Sunyer J,

Ghantous A, Pershagen G, Holland N, Murphy SK, DeMeo DL, Burchard EG, Ladd-Acosta

C, Snieder H, Nystad W, Koppelman GH, Relton CL, Jaddoe VW, Wilcox A, Melén E,

London SJ. DNA Methylation in Newborns and Maternal Smoking in Pregnancy:

Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96.

doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. PubMed PMID: 27040690; PubMed

Central PMCID: PMC4833289.

35: Brescianini S, Fagnani C, Aquilini E, Annesi-Maesano I, Stazi MA. Early

respiratory infections: the role of passive smoking in gene-environment

interaction. Eur J Public Health. 2016 Jun;26(3):401-3. doi:

10.1093/eurpub/ckw027. Epub 2016 Mar 24. PubMed PMID: 27013548.

36: Vardavas CI, Hohmann C, Patelarou E, Martinez D, Henderson AJ, Granell R,

Sunyer J, Torrent M, Fantini MP, Gori D, Annesi-Maesano I, Slama R, Duijts L, de

Jongste JC, Aurrekoetxea JJ, Basterrechea M, Morales E, Ballester F, Murcia M,

Thijs C, Mommers M, Kuehni CE, Gaillard EA, Tischer C, Heinrich J, Pizzi C, Zugna

D, Gehring U, Wijga A, Chatzi L, Vassilaki M, Bergström A, Eller E, Lau S, Keil

T, Nieuwenhuijsen M, Kogevinas M. The independent role of prenatal and postnatal

exposure to active and passive smoking on the development of early wheeze in

children. Eur Respir J. 2016 Mar 10. pii: ERJ-01016-2015. doi:

10.1183/13993003.01016-2015. [Epub ahead of print] PubMed PMID: 26965294.

37: Yuan WL, Rigal N, Monnery-Patris S, Chabanet C, Forhan A, Charles MA, de

Lauzon-Guillain B; EDEN mother-child cohort Study Group. Early determinants of

food liking among 5y-old children: a longitudinal study from the EDEN

mother-child cohort. Int J Behav Nutr Phys Act. 2016 Feb 15;13:20. doi:

10.1186/s12966-016-0342-5. PubMed PMID: 26876058; PubMed Central PMCID:

PMC4753648.

38: D'Amato G, Vitale C, D'Amato M, Cecchi L, Liccardi G, Molino A, Vatrella A,

Sanduzzi A, Maesano C, Annesi-Maesano I. Thunderstorm-related asthma: what

happens and why. Clin Exp Allergy. 2016 Mar;46(3):390-6. doi: 10.1111/cea.12709.

Review. PubMed PMID: 26765082.

39: Carreiro-Martins P, Papoila AL, Caires I, Azevedo S, Cano MM, Virella D,

Leiria-Pinto P, Teixeira JP, Rosado-Pinto J, Annesi-Maesano I, Neuparth N. Effect

of indoor air quality of day care centers in children with different

predisposition for asthma. Pediatr Allergy Immunol. 2016 May;27(3):299-306. doi:

10.1111/pai.12521. Epub 2016 Jan 26. PubMed PMID: 26663443.

40: Heude B, Forhan A, Slama R, Douhaud L, Bedel S, Saurel-Cubizolles MJ, Hankard

R, Thiebaugeorges O, De Agostini M, Annesi-Maesano I, Kaminski M, Charles MA;

EDEN mother-child cohort study group. Cohort Profile: The EDEN mother-child

cohort on the prenatal and early postnatal determinants of child health and

development. Int J Epidemiol. 2016 Apr;45(2):353-63. doi: 10.1093/ije/dyv151.

Epub 2015 Aug 17. PubMed PMID: 26283636.

41: Dallongeville A, Costet N, Zmirou-Navier D, Le Bot B, Chevrier C, Deguen S,

Annesi-Maesano I, Blanchard O. Volatile and semi-volatile organic compounds of

respiratory health relevance in French dwellings. Indoor Air. 2016

Jun;26(3):426-38. doi: 10.1111/ina.12225. Epub 2015 Jun 15. PubMed PMID:

26010323.

42. Guilleminault L, Just J, Humbert M, Leroyer C, Epaud R. [Seasonality in asthma: Impact and treatments]. Presse Med. 2016 Mar 30. pii: S0755-4982(16)00050-6. doi: 10.1016/j.lpm.2016.01.019. [Epub ahead of print] French. PubMed PMID: 27039335.

43. Berger W, Meltzer EO, Amar N, Fox AT, Just J, Muraro A, Nieto A, Valovirta E, Wickman M, Bousquet J. Efficacy of MP-AzeFlu in children with seasonal allergic rhinitis: Importance of paediatric symptom assessment. Pediatr Allergy Immunol. 2016 Mar;27(2):126-33. doi: 10.1111/pai.12540. PubMed PMID: 26928753.

44. Dizier MH, Nadif R, Margaritte-Jeannin P, Barton SJ, Sarnowski C, Gagné-Ouellet V, Brossard M, Lavielle N, Just J, Lathrop M, Holloway JW, Laprise C, Bouzigon E, Demenais F. Interaction between the DNAH9 gene and early smoke exposure in bronchial hyperresponsiveness. Eur Respir J. 2016 Apr;47(4):1072-81. doi: 10.1183/13993003.00849-2015. Epub 2016 Jan 21. PubMed PMID: 26797031.

45. Siroux V, Boudier A, Dolgopoloff M, Chanoine S, Bousquet J, Gormand F, Just J, Le Moual N, Nadif R, Pison C, Varraso R, Matran R, Pin I. Forced midexpiratory flow between 25% and 75% of forced vital capacity is associated with long-term persistence of asthma and poor asthma outcomes. J Allergy Clin Immunol. 2016 Jun;137(6):1709-1716.e6. doi: 10.1016/j.jaci.2015.10.029. Epub 2015 Dec 11. PubMed PMID: 26688518.

46. Deschildre A, Elegbédé CF, Just J, Bruyère O, Van der Brempt X, Papadopoulos A, Beaudouin E, Renaudin JM, Crepet A, Moneret-Vautrin DA. Peanut-allergic patients in the MIRABEL survey: characteristics, allergists' dietary advice and lessons from real life. Clin Exp Allergy. 2016 Apr;46(4):610-20. doi: 10.1111/cea.12681. PubMed PMID: 26588036.